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C. P. Suryawanshi ¹, V. R. Patil ¹, R. Y. Chaudhari ¹, M. K. Kale ², S. D. Firake ², R. B. Pimprikar ³, M. D. Patil ³, S. B. Yeshwante ³, D. S. Saindanem ³

Affiliations
1 Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon 425201, IN
3 Nagaon Education Society's Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS), IN

Abstract

The Parkinson's disease is mainly distinguished from other diseases based on the key feature that is tremors. Oxotremorine induced oxidative stress is implicated as a common pathway in development of Parkinson's symptoms like, tremor, salivation and temperature variation. Hence Oxotremorine-induced tremor model was used to evaluate antiparkinsonian drugs. Different extracts of plant of Cassia tora such as, petroleum ether (200mg/kg) p.o., methanolic (200mg/kg) p.o. and ethyl acetate extract (200mg/Kg) p.o. were used to investigate antiparkinsonian effect on oxotremorine induced Parkinson's symptoms in mice. Procyclidine, an anticholinergic, antiparkinsonian drug was administered as a standard drug at a dose of 5mg/kg p.o., 1hr prior the administration of oxotremorine (0.5mg/kg) S.C. Methanolic extract at 200mg/kg p.o route of administration decreased (p<0.05) Parkinson's symptoms, while petroleum ether extract (200mg/kg)p.o and ethyl acetate extract (200mg/kg)p.o shows moderate action. This study suggests that cassia tora is a plant with possible therapeutic value for Parkinson's disease.

Keywords

Parkinson's Disease, Oxotremorine, Tremor, Procyclidine.

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S. B. Yeshwante ¹, A. R. Juvekar ¹, R. B. Pimprikar ², R. T. Kakade ², M. Tabrej ², M. K. Kale ³, S. D. Firke ³

Affiliations
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN

Abstract

The methanolic extract of Dillenia indica leaves have been reported to possess anti-inflammatory activity. Inflammatory mediators such as prostaglandins and bradykinins are involved in the pathogenesis of diarrhea. The aim of the present work was to evaluate the anti-diarrheal activity of aqueous and methanolic extracts of Dillenia indica leaves. The anti-diarrheal activity was evaluated using Castor oil induced diarrhea model and different parameters such as onset of diarrhea and total number of feaces for the period of 4 hours. were observed. The results of test group were compared with Vehicle control group using one way ANOVA followed by Dunnett's Test. The results revelaled that both extracts at doses of 200 and 400mg/kg P.O. showed significant (P<0.01) prolongation of onset of diarrhea and significant (P<0.01) reduction in total number of feaces after 2^nd hour of treatment while dose of 100mg does not show any activity. From the results it can be concluded that the inhibition of the diarrhea and prolongation of onset might be due to inhibition of inflammatory mediator release and phyto-constituents such as flavonoids and tannins may have also contributed to the anti-diarrheal activity.

Keywords

Dillenia indica, Dilleniaceae, Castor Oil, Aqueous and Methanolic Extracts.

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D. S. Saindane ¹, A. S. Kulkarn ², A. N. Sagri ², R. B. Pimprikar ³, S. B. Yeshwante ³, C. P. Suryawanshi ³, S. D. Firke ⁴, M. K. Kale ⁴

Affiliations
1 Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
2 Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
3 Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), IN

Abstract

This study compares the physicochemical properties of cefixime (CFX) solid dispersions prepared by freeze drying method. Solid dispersions of cefixime in poloxamer 188 were prepared and characterized by intrinsic dissolution, powder X-ray diffraction, Fourier transform infrared spectroscopy and Scanning electron microscopy. CFX:Poloxamer 188 solid dispersions showed increased dissolution rate than pure CFX. The Infrared spectroscopic studies showed interaction between CFX and Poloxamer 188 in solid dispersions. The scanning electron microscopy studies showed decrease in particle size of binary system as compared to particle of pure drug. The amorphous state of CFX coupled with presence of interaction between drug and Poloxamer 188. However, the antimicrobial activity of CFX was increased significantly by Poloxamer 188 against S. aureus and E. coli. The solid dispersion technique of CFX:Poloxamer 188 binary system provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.

Keywords

Cefixime, Solid Dispersion, Poloxamer 188, Freeze Drying, Dissolution Rate, Binary System.

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S. V. Chordiya ¹, R. B. Pimprikar ², S. B. Yeshwante ², Tanvir Shaikh ², P. N. Patil ³, M. K. Kale ⁴, B. M. Firke ⁴

Affiliations
1 Varadvinayak Sankul, Flat No-1, Bajrang Chawk, N-8, CIDCO, Aurangabad-431005, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 Science College, Nagaon, Dhule (M.S.), IN
4 KYDSCT,s College of Pharmacy, Sakegaon, Jalgaon (M.S.), IN

Abstract

Worm infestation is one of the major global public health problems, more so in tropical countries. Worms can cause various GI and general symptoms. In addition some of them can cause blood lose, nutritional deficiencies. Helminthiasis is among the most important animal health problems. The disease is highly prevalent particularly in developing countries. In present study Aqueous and ethanolic extract of Hiptage benghalensis (L) kurz, belonging to family Malpighiaceae leaves were investigated for anthelmintic activity. The extracts were used in concertrations of 5, 10 and 25mg/ml and the process involves determination of time of paralysis and time of death of Pheritima posthuma (earth worm). Among the two extracts tested, aqueous extract showed more potent activity against the worm when compared with standard drug Piperazine citrate.

Keywords

Anthelmintic, Hiptage Bengalensis, Piperazine Citrate, Aqueous Extract.

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